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doi: 10.1146/annurev-pharmtox-010611-134609

Therefore, when evaluating the efficacy of IGF-1, comparisons should be made at the same GH cutoff levels

Specifically, PRMT1 enhanced the protein function of UBE2m through arginine methylation at R169, and increased the neddylation level and protein stability of NEDD4, thereby inducing PPAR ubiquitination